https://www.mandicmuleclab.com/home daily 1.0 2022-05-21 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603806943223-1GU3EPEM4U9B5C3XA3EZ/laboratorij_final.png Home https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603807422520-Q7IZWBRERZH7400H6C1O/laboratorij_final.png Home alt ““ https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603811671402-ONYENTLZNWC67WT78HS5/DO2A0612.jpg Home https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603811617478-EA3YG5LMPIGB1WO0ZNDA/_DXL1376.jpg Home https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603811562847-C7W8DQAMYMT33RG97I3O/_DXL1365.jpg Home https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604583460898-3RMV4ME82H5QXK39EJP3/_DXL1452.jpg Home Group Leader/ Prof. dr. Ines Mandić-Mulec https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584223877-18ZLP1N7MV74WWAEIRHE/_DXL1328.jpg Home Doc. dr. Iztok Dogša https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584315907-ME90O3B90NVILJSV8FB6/_DXL1150.jpg Home Asist. dr. Polonca Štefanič https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584316695-JUAIIJYVB2Y4QC5LOH9X/_DXL1276.jpg Home Doc. dr. Tjaša Danevčič https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584351506-L4U2S9IZOTMRPJ5E2RGN/_DXL1106.jpg Home Doc. dr. Barbara Kraigher https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584121123-ASW0CMIRFP92SHV5ZSYL/_DXL1083.jpg Home Technician, Simona Leskovec https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584386257-HCM8M5FTI4BYNW9R3H5R/_DXL1545.jpg Home Asist. dr. Eva Kovačec https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584560773-YKVMNYG4L2P180QWYIMY/_DXL1172.jpg Home PhD. Student Katarina Belcijan https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584412280-5U8W2EWD9DYJK8G17M8U/_DXL1201.jpg Home PhD. Student Mihael Špacapan https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584498310-XB6KD4E5FPV9ODV7V1EN/_DXL1128.jpg Home PhD. Student Maja Bolješić https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584465641-NDRE23HJ1O153HPFBBX0/_DXL1239.jpg Home PhD. Student Andi Erega https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604584591524-E91TUGZ5V9IFIXI6KGUE/_DXL1358.jpg Home Prof. dr. David Stopar https://www.mandicmuleclab.com/team daily 0.75 2022-05-21 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603971379116-WYXMZQQQMV3BFVHARUDF/_DXL1470.jpg Team - PROF. DR INES MANDIC-MULEC https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610976529472-BLHFC6ADFBVH0ZH45WFW/_DXL1276.jpg Team - DOC.DR. TJAŠA DENEVČIČ https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603970435351-QBJHPCQZTKGUGA4D0JAV/_DXL1545.jpg Team - ASIST.DR. EVA KOVAČEVEC https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603970115777-RF5CUQEMYPQ4GCKKKRGB/_DXL1328.jpg Team - ASSIST. PROF. DR. IZTOK DOGŠA https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603970199353-0DSUGSVB6FKYEDGJUGOK/_DXL1150.jpg Team - ASIST.DR. POLONCA ŠTEFANIČ https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610976742719-DQ0QPO31B485XLN7UYU1/_DXL1083.jpg Team - TECHNICIAN SIMONA LESKOVEC https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610978967078-9NEB5R9B2YWE3ID9DAB4/_DXL1106.jpg Team - DOC. DR. BARBARA KRAIGHER https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610977122563-MVH08QK5MHBNWHZ0SO1U/blue.png Team SARA GORŠEK https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610979364938-0ETJANBP1VSKD0FLHLAP/blue.png Team - DR. KATARINA ŠIMUNOVIĆ https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610978482138-LVRUJ1ZV2N5535Y00GLT/blue.png Team ELI PODNAR https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603977650386-O9C2ZX6ABL5LVXVB6HM8/_DXL1172.jpg Team KATARINA BELCIJAN https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603970640342-A82FON17O8GZPJVJSDT5/_DXL1239.jpg Team ANDI EREGA https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610978552004-OEAGBUWJX2ANDG3AP96G/blue.png Team MOJCA KRAJNC https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603971708516-Q7J0BUU1XAXCQNV7IZMV/_DXL1128.jpg Team - DR. MAJA BOLJEŠIĆ https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610978834308-HW0PU9DF9WHB9SQ6FAVE/blue.png Team - DR. LUKA AUŠEC https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603977567095-RKOECON3ADQYIGKXV3YM/_DXL1201.jpg Team - DR. MIHAEL ŠPACAPAN https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610978815918-2P4I25MAFHYP3LZX7ICT/blue.png Team - DR. ANA DRAGOŠ https://www.mandicmuleclab.com/contact daily 0.75 2020-11-05 https://www.mandicmuleclab.com/dr-ines-mandic-mulec daily 0.75 2022-05-21 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/9e0bd19f-2a83-4205-b3e5-a2fda7864f02/_DXL1456.jpg Prof. Dr. Ines Mandic-Mulec - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mandicmuleclab.com/terms-and-conditions daily 0.75 2020-10-29 https://www.mandicmuleclab.com/privacy-policy daily 0.75 2020-11-05 https://www.mandicmuleclab.com/faqs daily 0.75 2020-10-29 https://www.mandicmuleclab.com/collaborators daily 0.75 2020-11-05 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603977948825-W2WK0C212DBXEI70R6A3/_DXL1358.jpg Collaborators - PROF.DR. DAVID STOPAR The main goal of prof. dr. David Stopar’s research is to understand microbial biofilms, their development and rheology as well as ways and means to control their growth. In his research he combines microbiology, molecular biology, biochemistry and biophysics tools. Within Program Group: Prof. dr. David Stopar Prof. dr. Sonja Smole Možina Prof. dr. Hrvoje Petković, Acies bio d.o.o. https://www.mandicmuleclab.com/research daily 0.75 2022-05-21 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610982410499-E2VRZT6B0PZOWDMHK39P/PATHOGEN.png Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604311862671-M4G1XU9A8IJFQ8N11BQT/Experiment-370.czi+-+Experiment-370.czi+%231+-+C%3D0-2.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604311791280-K5WBCKNLBFNV7ZIIR03R/delS2+mikrot-0060-1.png Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604311278438-A2IJ6BD251J2E5R3ROD9/Biofilm_63x-1.png Research & Publications - Significance for Science Rapid development of microflow (MF) technology in recent years will be the starting point for the development of microflow bioreactors, which will enable unique highly controlled conditions for fundamental as well as applied studies on bacterial growth, metabolism and multicellularity. This project will demonstrate that phenomena as diverse as biofilm formation, riboflavin biosynthesis and biosensing in scientifically and industrially extremely relevant bacterium B. subtilis can be investigated with unprecedented throughput, precision and insight by using state-of-the-art microfluidics and cross-sectorial collaboration. https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1610982940218-5ATTIK4NPT5LA4V0Q38Z/Horizon.png Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604577536840-74TLM5AFIF97W3DPABLP/image009.jpg Research & Publications - Significance for Science The project is of fundamental importance as it will increase our understanding of cell-cell signalling mechanisms, kin discrimination and the impact and responses of genetically diverse bioinoculant communities. The approach is novel and hypothesis-driven and experiments will be designed based on ecological and evolutionary theory. The research has relevance to the wide range of signal-based and other interactive processes occurring in soil or on plant roots. The use of B. subtilis, a key, commercially important, environmentally friendly (GRAS), biocontrol agent provides additional relevance, because of its action against plant pathogens and growth promotion of economically important crops. Hypotheses that will be tested in this project are highly relevant for understanding of social evolution, understanding of fundamental biological principles of social interactions, mechanism of bacterial communications and plant response to microbial interactions. The state of the art comprises advanced methods in confocal microscopy, transcriptomic analyses and genetic engineering of bacterial strains together with mathematical modeling of social networks and will further advance these methodologies. Global population increases and climate change pose a challenge to worldwide crop production and we are in urgent need of innovative solutions to combat abiotic stress, pathogens, and pests and PGPR represents a key solution to solve these challenges. Furthermore, Slovenia has limited agricultural lands and eco-friendly technologies and PGPR represent solution to preserve the productivity of our agricultural soils. The project will strengthen collaborations between three highly complementary Slovenian research groups in addition to international collaborations. Due to multidisciplinary approach the proposed scientific hypotheses will lead to important discoveries and high impact publications in the best journals, potentially also additional EU/international projects, in the medium-term, and in the long run provide opportunities for patenting and commercial exploitation. https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604577629386-0IMRNJTD9MPT9IJ5F788/group1.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604577679574-NUYIO65WM210OOHG5KGW/group2.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604314948108-42ZL2FUYKV0UEF3CJYR2/image008.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604314890600-JGZJ07A0VFCTV6AJP4ST/image007.jpg Research & Publications - Significance for Science The project is based on the exceptional recent discovery of kin discrimination and years of research in the field of ecology and social interactions of Bacillus subtilis, which has for decades been an excellent model organism for basic research in biofilms, horizontal gene transfer, swarming, sporulation, and is of broad interest for many research groups and industry around the world. Furthermore, this soil and plant-root associated bacterium B. subtilis is useful for the health of the plants. The proposed research is linked to the interaction of B. subtilis with plants and the plant pathogen Ralstonia solanacearum. The projects combines ecological and molecular approaches to test five interesting scientific hypotheses that address the evolutionary importance of kin discrimination, its influence on horizontal gene transfer and bacterial territoriality and combines this knowledge with application of these bacteria in plant support. The hypotheses are of fundamental importance and have not yet been confirmed in the context of bacterial kin discrimination. https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604313940318-MGVK9ERA3AYMSFZQH7PL/image001.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604315343318-MKUWCENQ1E74U65A7M1O/image005.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604583102585-C35SDS1HC2ZYY2MZ2148/Pathogen.png Research & Publications - Significance for Science Social microbiology is an emerging and dynamic field of research that is changing our perceptions of the microbial world and we believe that the results of this project will further boost our understanding of microbial social interactions including the effect of sociality on mechanical properties of mixed species biofilms, the distribution of cell clusters in these multicellular structures and secretions that are induced by interactions. https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604315310235-MXWGN5QLPTEY5MPYF6XW/image004.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604582846721-TAAXNIQF3QZ3TDXWR5NV/Meta.png Research & Publications - Significance for Science Laccase are oxidoreductase that are highly versatile enzymes and of high interest for many industrial and environmental applications including paper and textile industry, pharmaceutical or food industry but are also of high interest as enzymes added to increase efficiency of biofuel production or removal of toxic chemicals from the environment. The results gained within this project were published in several eminent journals and have brought invitations to present results at foreign universities and international conferences including an invited lecture at the most important EU conference in Europe (FEMS) as well as the request to organize and chair the section on soil metagenomics. The latter is the prime subject of this project which has strongly benefited from collaborations with members of the METAEXPLORE FP 7 projects. https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604316469235-ROMAIKPXJUY3EUTLIF0H/image002.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604582474991-7C3LAH315E5GI5NCOHUN/Soil3.png Research & Publications - Significance for Science Bacterial intercellular signaling is essential for coordination of survival strategies at the population level and understanding of this process is important for optimization of procedures applying bacteria as production organisms in industry, as probiotics for human health and husbandry or as biopesticides in agriculture. The project ‘Ecology of social interactions of Bacillus subtilis aimed to understand bacterial communication by focusing on the ComQXPA quorum sensing (QS) system. This QS system is especially interesting due to its high polymorphism, which increases the specificity of the response and prevents communication between strains of different communication types (pherotypes). Using in vitro and in situ models, we showed that pherotypes strongly correlate with ecotypes broadening our understanding of evolutionary forces contributing to diversification of pherotypes (Štefanič et al., Env. Microbiol., 2012). In addition we provided through a bioinformatics analysis a novel insight into the distribution of ComQXPA QS systems in sequenced bacterial genomes (Dogša et al ., PloS one 2014) as well as we have shown that strains with diverse communication loci colonize one tomato plant (Oslizlo et a, Environmental. Microbiol reports, 2015). We believe that this will encourage research of ComQXPA QS systems in other bacterial species. https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1604316448037-FNVI8YSLSQ40N412VICL/image003.jpg Research & Publications https://www.mandicmuleclab.com/classes daily 0.75 2020-11-05 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968419177-BL0WC8UIBGR8VFTFMKWV/_DXL1399.jpg Classes https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968539272-HD9DD59N2MRN5608OU3I/_DXL1772.jpg Classes https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968516546-WQH8593HHK2UJYGBMD9H/_DXL1745.jpg Classes https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968760061-03Z2EQNRRH5OPUJJW2GU/_DXL1377.jpg Classes https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968401804-OS2FOGUQV30W30DNEEOY/_DXL1394.jpg Classes https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968499936-TW9AW3DTVAWQOVOCY93U/_DXL1438.jpg Classes https://www.mandicmuleclab.com/classes/master-study-programmes monthly 0.5 2020-11-05 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603967882563-H344QB0GK7EBUQ0X16LR/DO2A0601.jpg Classes - Master Study Programmes alt="" https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603967929767-4GB1OPA02UGQ41N23YD8/DO2A0639.jpg Classes - Master Study Programmes alt="" https://www.mandicmuleclab.com/classes/bachelor-study-programmes monthly 0.5 2020-11-05 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603967435348-K015EOGHMHWU5NJ5HOY0/_DXL1755.jpg Classes - Bachelor Study Programmes alt="" https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603967402469-L74SPS6PPEFQGLVF5094/_DXL1758.jpg Classes - Bachelor Study Programmes alt="" https://www.mandicmuleclab.com/classes/doctoral-study-programme-in-biosciences monthly 0.5 2020-11-05 https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968280247-QVVNIHT9V9PXMUL8YC3M/_DXL1403.jpg Classes - Doctoral Study Programme in Biosciences alt="" https://images.squarespace-cdn.com/content/v1/5f97ff7eafc2266601eff15a/1603968250634-HRB74TRU8H62CPUEM9H2/DO2A0699.jpg Classes - Doctoral Study Programme in Biosciences alt=""